Genom-weite Studien bzw. - Projekte
ENGAGE - European Network for Genetic and Genomic Epidemiology (2008 - 2012)
ENGAGE has, as its central objective, the translation of the wealth of data emerging from large-scale research efforts in molecular epidemiology into information of direct relevance to future advances in clinical medicine. ENGAGE will do this through the integration of very large-scale genetic and phenotypic data already available from a substantial number of large and well-characterized European (and other) sample sets of various types. KORA-gen brings its genome-wide study KORA F3/S3 500K and KORA S4 as replication sample into the consortium.
KORA-gen contributed successfully to two international genome-wide association studies using Affymetrix 100K and 500K Genechips:
- Significant associations have been found for genes regulating the QT-interval including the identification of novel genes previously not known to be involved in cardiac repolarization (Arking/Pfeufer et al, Nat. Genetics, 2006).
- A common genetic variant near the INSIG2 gene has shown an association with obesity (Herbert et al, Science, 2006)