Infrastructure to provide phenotypes, genotypes and biosamples for collaborative genetic epidemiological research

About this platform

To meet the manifold demands of researchers with genetic and molecular questions KORA-gen fulfills the following prerequisites for successful genetic-epidemiological research:
- representative samples from the general population,
- well characterized disease phenotypes and intermediate phenotypes,
- information on environmental factors,
- availability of genomic DNA, serum, plasma and urine, as well as EBV immortalized cell lines.

Latest publication

Doering A, Gieger C, Mehta D, Gohlke H, Prokisch H, Coassin S, Fischer G, Henke K, Klopp N, Kronenberg F, Paulweber B, Pfeufer A, Rosskopf D, Voelzke H, Illig T, Meitinger T, Wichmann HE, Meisinger C:

SLC2A9 influences uric acid concentrations with pronounced sex-specific effects

Nat Genet 40(4), 430-436 (2008)

Additional information about KORA-gen

KORA-gen - Resource for Population Genetics, Controls and a Broad Spectrum of Disease Phenotypes
Gesundheitswesen 2005;67 Sonderheft 1:S26 - S30;(.pdf, 660 KB, 5 S.)


Services for science

The Helmholtz-Zentrum München (formerly known as GSF - National Research Center for Environment and Health in Germany) has established the population-based KORA research platform (Cooperative Health Research in the Region of Augsburg, Southern Germany) which has evolved from the WHO MONICA study (Monitoring of Trends and Determinants of Cardiovascular Disease). The infrastructure is used by several Helmholtz Zentrum München institutes and their partners. In a large number of collaborative projects a broad spectrum of scientific questions has been analyzed.

In total, four population based health surveys have been conducted between 1984 and 2000 with 18000 participants in the age range of 25 to 74 years, and a biological specimen bank was established in order to enable scientists to perform epidemiologic research with respect to molecular and genetic questions. The KORA study center conducts regular follow-up investigations and has collected a wealth of information on sociodemography, general medical history, environmental factors, smoking, nutrition, alcohol consumption, and various laboratory parameters. This unique resource will be increased further by follow-up studies of the cohort.

To learn more about KORA and GWA's, please read:
KORA - a success story for genome-wide association studies (.pdf).